Use of Information Measures and Their Approximations to Detect Predictive Gene-Gene Interaction

There is a neat paper that just appeared in the journal Entropy. The authors show how entropy-based methods can detect certain kinds of interactions that are not found with logistic regression. This builds on our previous work (e.g. Moore 2006, Hu 2013) introducing and expanding entropy as a useful metric for epistasis analysis in human genetics. We have recently reviewed these methods here. Others have reviewed these approaches here.