A nice new essay in Trends in Genetics
Campbell RF, McGrath PT, Paaby AB. Analysis of Epistasis in Natural Traits Using Model Organisms. Trends Genet. 2018 [PubMed]
Highlights
Identification
of statistical epistasis in natural populations remains challenging due
to the relationship between allele frequency and statistical power.
Artificial
populations have been constructed in model organisms to detect
statistical epistasis between two regions of the genome; however, it is
difficult to use these results to understand how epistasis operates in
natural populations.
Studies of focal perturbations
in defined genetic backgrounds suggests that natural selection can
influence the types of nonadditive relationships that exist.
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