We have just published this open access editorial BioData Mining
on whether 'big data' is a 21st century Maginot line
. This is relevant because we as scientists sometimes let the data define the research questions rather than the other way around. As the size and complexity of data grows we may find ourselves asking simpler and simpler questions only some of which are important to advancing our understanding of human health and disease.
Huang X, Jennings SF, Bruce B, Buchan A, Cai L, Chen P, Cramer CL, Guan W, Hilgert UK, Jiang H, Li Z, McClure G, McMullen DF, Nanduri B, Perkins A, Rekepalli B, Salem S, Specker J, Walker K, Wunsch D, Xiong D, Zhang S, Zhang Y, Zhao Z, Moore JH. Big data - a 21st century science Maginot Line? No-boundary thinking: shifting from the big data paradigm. BioData Min. 2015 Feb 6;8:7. [PDF
See also our previous related essay on 'no boundary thinking' in bioinformatics.
Huang X, Bruce B, Buchan A, Congdon CB, Cramer CL, Jennings SF, Jiang H, Li Z, McClure G, McMullen R, Moore JH, Nanduri B, Peckham J, Perkins A, Polson SW, Rekepalli B, Salem S, Specker J, Wunsch D, Xiong D, Zhang S, Zhao Z. No-boundary thinking in bioinformatics research. BioData Min. 2013 Nov 6;6(1):19. [PDF
Labels: big data, bioinformatics