Epistasis Blog

From the Computational Genetics Laboratory at the University of Pennsylvania (www.epistasis.org)

Friday, January 28, 2005

Software: Open-Source MDR

Multifactor Dimensionality Reduction (MDR) is a nonparametric and genetic model-free alternative to logistic regression for detecting and characterizing nonlinear interactions among discrete genetic and environmental attributes. The MDR method combines attribute selection, attribute construction, and classification with cross-validation and permutation testing to provide a comprehensive and powerful approach to detecting nonlinear interactions. See Moore (Expert Review of Molecular Diagnostics, 4:795-803, 2004) for a recent review of the MDR method and its application to real data.

We will be releasing an open-source, JAVA version of the MDR software sometime in February. Please check the 'Open-Source MDR Project' web page for updates.

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