Epistasis Blog

From the Computational Genetics Laboratory at the University of Pennsylvania (www.epistasis.org)

Monday, February 20, 2006

Digital Genetics

Dr. Chris Adami has a new review paper on digital genetics. We have previously written that digital experiments may be useful for understanding the relationship between biological and statistical epistasis (see Moore and Williams, Bioessays. 2005 Jun;27(6):637-46.).

Adami C. Digital genetics: unravelling the genetic basis of evolution. Nat Rev Genet. 2006 Feb;7(2):109-18.

Abstract:

Digital genetics, or the genetics of digital organisms, is a new field of research that has become possible as a result of the remarkable power of evolution experiments that use computers. Self-replicating strands of computer code that inhabit specially prepared computers can mutate, evolve and adapt to their environment. Digital organisms make it easy to conduct repeatable, controlled experiments, which have a perfect genetic 'fossil record'. This allows researchers to address fundamental questions about the genetic basis of the evolution of complexity, genome organization, robustness and evolvability, and to test the consequences of mutations, including their interaction and recombination, on the fate of populations and lineages.

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