Epistasis Blog

From the Computational Genetics Laboratory at the University of Pennsylvania (www.epistasis.org)

Wednesday, April 23, 2008

Introduction to Gene-Gene Interactions

I published a short introduction to gene-gene interactions in Current Protocols in Human Genetics in 2004. Interestingly, this chapter just appeared on PubMed. If you see this and are interested in reading it you should know that I updated the chapter in January. The new 2008 version doesn't seem to be published yet. If you would like a copy of the new version feel free to email me.

Moore JH. Analysis of gene-gene interactions. Curr Protoc Hum Genet. 2004 Feb;Chapter 1:Unit1.14. [PubMed]

The goal of this unit is to introduce gene-gene interactions or epistasis as a significant complicating factor in the search for disease susceptibility genes. This unit begins with an overview of gene-gene interactions and why they are likely to be common; then, it reviews several statistical and computational methods for detecting and characterizing genes whose effects are dependent on other genes. The focus of this unit is genetic association studies of discrete and quantitative traits since most of the methods for detecting gene-gene interactions have been developed specifically for these study designs.

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