Epistasis Blog

From the Computational Genetics Laboratory at the University of Pennsylvania (www.epistasis.org)

Friday, August 14, 2009

Casey S. Greene, Ph.D.

Casey Greene from my lab successfully defended his Ph.D. today. The title of his dissertation is "Relief-based bioinformatics methods for the analysis of epistasis in genetic association studies". Nice job Casey!

Casey is off to the Lewis-Sigler Institute for Integrative Genomics at Princeton University where he will be doing a postdoc with Dr. Olga Troyanskaya.

His dissertation chapters include the following papers:

Greene, C.S., Penrod, N.M., Williams, S.M., Moore, J.H. Failure to replicate a genetic association may provide important clues about genetic architecture. PLoS One 4, e5639 (2009). [PubMed]

Greene, C.S., Kiralis, J., Moore, J.H. Nature-inspired algorithms for the genetic analysis of epistasis in common human diseases: A theoretical assessment of wrapper vs. filter approaches. Proceedings of the IEEE Congress on Evolutionary Computation, pp. 800-807 (2009). [IEEE]

Greene, C.S., Penrod, N.M., Kiralis, J., Moore, J.H. Spatially uniform ReliefF (SURF) for computationally-efficient filtering of gene-gene interactions. BioData Mining, in press (2009).

Greene, C.S., Kiralis, J., Moore, J.H. The informative extremes: Using both nearest and farthest neighbors can improve Relief algorithms in the domain of human genetics. in review.

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