Epistasis Blog

From the Computational Genetics Laboratory at the University of Pennsylvania (www.epistasis.org)

Thursday, March 24, 2011

Interactome Networks and Human Disease

Consider whether we should be doing genetic analysis one SNP at a time after reading this paper.

Vidal M, Cusick ME, Barabási AL. Interactome networks and human disease. Cell. 2011 Mar 18;144(6):986-98. [PubMed]

Abstract

Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.

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