The Challenges of Personalized Medicine and Genomics

This new piece in Science magazine summarizes nicely some of my concerns about the integration of whole genome sequencing into the clinic. I have tweeted about a number of these issues. A must read.

Liam R. Brunham, Michael R. Hayden. Whole-Genome Sequencing: The New Standard of Care? Science 336;1112-1113. [Science]

Rapid advances in DNA sequencing technology have made whole-genome sequencing (WGS) both technically and economically feasible. WGS has been used with great effect in specific settings to clarify molecular diagnosis and even to guide therapy. But are we ready for the routine use of WGS in the care of healthy individuals?