Here are a few new reviews on synthetic biology. I think the potential to use synthetic gene networks to understand epistasis is enormous.
Bhalerao KD. Synthetic gene networks: the next wave in biotechnology? Trends Biotechnol. 2009 Jun;27(6):368-74.[PubMed]
Deplazes A. Piecing together a puzzle. An exposition of synthetic biology. EMBO Rep. 2009 May;10(5):428-32. [PubMed]
Purnick PE, Weiss R. The second wave of synthetic biology: from modules to systems. Nat Rev Mol Cell Biol. 2009 Jun;10(6):410-22.[PubMed]