Gene-Environment Interaction in Asthma

The complexity of the genotype-phenotype mapping relationship seems to be catching on in asthma genetics. Why would gene-environment interaction not be excepted to play a role in asthma? Why would anyone investigate the genetic basis of asthma one SNP at a time? ...or one environment at a time?

von Mutius E. Gene-environment interactions in asthma. J Allergy Clin Immunol. 2009 Jan;123(1):3-11 [PubMed]

Martinez FD. Gene-environment interaction in complex diseases: asthma as an illustrative case. Novartis Found Symp. 2008;293:184-92 [PubMed]

See also my previous post on this topic.