Epistasis Blog

From the Computational Genetics Laboratory at the University of Pennsylvania (www.epistasis.org)

Wednesday, January 13, 2010

Epistatic Interactions

I don't agree with everything in this paper but it does provide some useful information.

VanderWeele, Tyler J. (2010) "Epistatic Interactions," Statistical Applications in Genetics and Molecular Biology: Vol. 9 : Iss. 1, Article 1. [PDF]

Abstract

The term "epistasis" is sometimes used to describe some form of statistical interaction between genetic factors and is alternatively sometimes used to describe instances in which the effect of a particular genetic variant is masked by a variant at another locus. In general statistical tests for interaction are of limited use in detecting "epistasis" in the sense of masking. It is, however, shown that there are relations between empirical data patterns and epistasis that have not been previously noted. These relations can sometimes be exploited to empirically test for "epistatic interactions" in the sense of the masking of the effect of a particular genetic variant by a variant at another locus.

1 Comments:

At 8:05 AM, Blogger alex said...

Would you be willing to enlarge on that with which you do and do not agree?

 

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