The April, 2010 issue of Genetic Epidemiology is packed with interesting papers that consider multilocus effects. IMHO, Genetic Epidemiology has been publishing more interesting papers than any of the top journals including Science, Nature and Nature Genetics. This is the place to look for research results that are likely to have an impact. Similarly, I find the content of the annual meeting of the International Genetic Epidemiology Society (IGES) to be very interestiing and useful. This is where the real dialogue about solving the missing heritability problem is happening.