Epistasis Blog

From the Computational Genetics Laboratory at the University of Pennsylvania (www.epistasis.org)

Sunday, November 28, 2010

Our Latest MDR Papers

Here are a few of our recently published papers on Multifactor Dimensionality Reduction (MDR). The first is a review while the next three report extensions of MDR for survivavl analysis, covariate adjustment and a robust approach that deals with the rare situation of having only a few genotype combinations contributing information. This work was supported by NIH grants R01 LM009012, R01 LM010098 and R01 AI59694.

Moore JH. Detecting, characterizing, and interpreting nonlinear gene-gene interactions using multifactor dimensionality reduction. Adv Genet. 2010;72:101-16. [PubMed]

Gui J, Moore JH, Kelsey KT, Marsit CJ, Karagas MR, Andrew AS. A novel survival multifactor dimensionality reduction method for detecting gene-gene interactions with application to bladder cancer prognosis. Hum Genet. 2010 Oct 28, in press. [PubMed]

Gui J, Andrew AS, Andrews P, Nelson HM, Kelsey KT, Karagas MR, Moore JH. A simple and computationally efficient sampling approach to covariate adjustment for multifactor dimensionality reduction analysis of epistasis. Hum Hered. 2010;70(3):219-25. [PubMed]

Gui J, Andrew AS, Andrews P, Nelson HM, Kelsey KT, Karagas MR, Moore JH. A robust multifactor dimensionality reduction method for detecting gene-gene interactions with application to the genetic analysis of bladder cancer susceptibility. Ann Hum Genet. 2010 Nov 22., in press. [PubMed]

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