Epistasis Blog

From the Computational Genetics Laboratory at the University of Pennsylvania (www.epistasis.org)

Saturday, March 26, 2005

Tree Scanning

Tree scanning is a new method for using haplotype trees in phenotype/genotype association studies. See:

Templeton et al. Tree scanning: a method for using haplotype trees in phenotype/genotype association studies. Genetics. 2005 Jan;169(1):441-53. [PubMed]

Posada et al. TreeScan: a bioinformatic application to search for genotype/phenotype associations using haplotype trees. Bioinformatics. 2005 Jan 28. [PubMed]

This work is related to Alan Templeton's work on cladistic analysis. The following paper extends the cladistic approach:

Durrant et al. Linkage disequilibrium mapping via cladistic analysis of single-nucleotide polymorphism haplotypes. Am J Hum Genet. 2004 Jul;75(1):35-43. [PubMed]

Here is an application of cladistic analysis to the liporptein lipase gene:

Templeton et al. Cladistic structure within the human Lipoprotein lipase gene and its implications for phenotypic association studies. Genetics. 2000 Nov;156(3):1259-75. [PubMed]

Here is an older review of cladistic analysis:

Templeton. Cladistic approaches to identifying determinants of variability in multifactorial phenotypes and the evolutionary significance of variation in the human genome. Ciba Found Symp. 1996;197:259-77. [PubMed]

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