Epistasis Blog

From the Computational Genetics Laboratory at the University of Pennsylvania (www.epistasis.org)

Thursday, July 21, 2005

Learning Petri net models of non-linear gene interactions

A recent paper by Mayo in BioSystems studies the use of Petri nets for building models of biochemical systems that are consistent with epistatic models of disease susceptibility.

Mayo M. Biosystems. 2005 Jul 14; [Epub ahead of print] [PubMed]

This work builds on our previous work in this area. See, for example:

Moore JH, Boczko EM, Summar ML. Connecting the dots between genes, biochemistry, and disease susceptibility: systems biology modeling in human genetics. Mol Genet Metab. 2005 Feb;84(2):104-11. [PubMed]

Moore JH, Hahn LW. Petri net modeling of high-order genetic systems using grammatical evolution. Biosystems. 2003 Nov;72(1-2):177-86. [PubMed]

For more information in Petri nets visit the Petri Nets World website.

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