Epistasis Blog

From the Computational Genetics Laboratory at the University of Pennsylvania (www.epistasis.org)

Friday, August 12, 2005

Epistasis in Autism detected using MDR

A new paper by Ma et al. in the American Journal of Human Genetics describes an interaction among GABA receptor subunit genes in Autism that was detected using our Multifactor Dimesnionality Reduction (MDR) method. More information on MDR can be found here. Our open-source MDR software package can be found here.

Ma DQ, Whitehead PL, Menold MM, Martin ER, Ashley-Koch AE, Mei H, Ritchie MD, Delong GR, Abramson RK, Wright HH, Cuccaro ML, Hussman JP, Gilbert JR, Pericak-Vance MA. Identification of Significant Association and Gene-Gene Interaction of GABA Receptor Subunit Genes in Autism. Am J Hum Genet. 2005 Sep;77(3):377-88. [PubMed]

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