Hints of hidden heritability in GWAS
This News and Views piece by Greg Gibson summarizes two recent GWAS papers published in Nature Genetics.
Gibson G. Hints of hidden heritability in GWAS. Nat Genet. 2010 Jul;42(7):558-60. [PubMed]
Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR, Madden PA, Heath AC, Martin NG, Montgomery GW, Goddard ME, Visscher PM. Common SNPs explain a large proportion of the heritability for human height. Nat Genet. 2010 Jul;42(7):565-9. [PubMed]
Park JH, Wacholder S, Gail MH, Peters U, Jacobs KB, Chanock SJ, Chatterjee N. Estimation of effect size distribution from genome-wide association studies and implications for future discoveries. Nat Genet. 2010 Jul;42(7):570-5. [PubMed]